Bruker ICON

ICON

A Paradigm Shift
in MR Imaging.

Just as researchers are creating breakthroughs in the understanding
of disease using animal models, so has Bruker created a paradigm
shift in pre-clinical phenotyping using MRI. Introducing the ICON™
compact, high-performance MRI system.

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MRI is the leading modality pre-clinically and clinically for anatomical and morphological imaging, in addition to providing exquisite functional and molecular whole body imaging in 2D and 3D. While providing sophisticated insights, conventional pre-clinical MRI systems are costly and complex to purchase, install and maintain. They often require shielded rooms and dedicated facilities, and their operation relies on significant MR expertise. Bruker’s ICON compact high-performance MRI system enables the scientist with no imaging expertise to access the power of MRI and quickly generate quantitative imaging results to answer their biological questions in vivo.

Summary of Key Benefits

The ICON compact high-performance MRI system provides the following benefits to the biological researcher:

  • No active fringe magnetic field - The ICON can be placed anywhere in a research facility (in a lab, next to other important modalities, behind the barrier)
  • Virtually maintenance-free
  • Easy-to-use software, simple workflow and pre-programmed sequences - lab technician with no prior MRI or imaging experience to quickly master the platform and perform highly effective MR-based imaging experiments
  • No dedicated facilities or shielded rooms, no isolation from other metal objects, simple siting and no dedicated power supplies or cooling required
  • Simple to install - imaging is usually performed by the end of the first day of installation
  • The ICON operates at a 1 Tesla field strength. This is the most suitable field strength and frequency in which to perform gadolinium-based contrast agent imaging due to the nature of the relaxivity curves of such agents. Aspect Imaging’s line of PhenoQuant contrast agents provides image enhancement benefits, targeting capabilities (for specific biomarkers) and further increases the breadth of applications that can be performed on the instrument
  • MRI is routinely used in the clinic. As such, the ICON is completely scalable and translatable from mouse to man as many of the clinical MRI approaches, sequences and applications can be scaled to be performed on the ICON
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Rapid Workflow, Powerful In Vivo Results

The simple workflow of the ICON system allows for the high throughput put imaging of
mice and rats and the quick generation of 2D and 3D quantitative results. Animals are
anesthetised typically using isoflurane, they are placed in the ICON small animal
handling unit with heating and physiological monitoring, and are then placed in the
ICON system for imaging.

ParaVision, Bruker’s powerful operating software allows the user to quickly set up a
study with the required parameters, to run a quick "scout" image and then to run one
of many imaging sequences. Images are generated in minutes and then exported for
further analysis.

Step 1

ICON Step 1

Mouse or rat is anesthetised and placed in the ICON small animal holder with the appropriate ICON imaging coil..

Step 2

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Animal is placed in the ICON instrument for imaging. A study session and appropriate imaging protocol are easily selected in the ParaVision software. Custom protocols are easily developed and saved.

Step 3

ICON Step 3

A "preview" image is generated to ensure optimal animal placement and image presentation. Once verified, the imaging sequence is initiated.

Step 4

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High-resolution images are generated in minutes and exported for further analysis and quantification.