PhenoQuant Contrast Agents

PhenoQuant
Contrast Agents

Contrast enhancement can be seen
throughout the whole mouse body, including
the kidneys, spleen and major blood vessels.




M2 images courtesy of Dr. W. Sun, Rutgers University

Aspect Imaging’s PhenoQuant™ line of contrast agents provide biologists with a suite of MR imaging agents that are optimized for the Bruker ICON and Mediso nanoScan platforms. PhenoQuant agents can be used to further extend the breadth of applications and imaging biomarkers that can be explored and quantified in vivo to generate powerful phenotyping in research and drug development.


PhenoQuant agents are available as:

Agent Use
Targeted Contrast Agents
Target specific biomarkers, like folic acid over-expressed/upregulated in tumor cells, integrin receptors and Low Density Lipoproteins (LDL) transporters
Vascular Permeability Contrast Agents Quantify vascular permeability in neo-formed vessels in tumor-bearing animal models


Compact MRI = Highest Contrast-based Molecular Sensitivity

The Bruker ICON™ and Mediso nanoScan® systems are the optimal MRI platforms for molecular imaging due to the advantages of the systems’ operating field—1 Tesla—for the imaging and detection of contrast agents. Unlike MR systems that operate at higher frequencies, the 40 MHz operating frequency of the ICON and nanoScan® systems ensures that scientists benefit from the attributes of the relaxivity curve to increase sensitivity in detecting and quantifying cellular activity that is targeted or enhanced through contrast agents on these compact, high-performance MRI platform.


Contrast imaging of C57 mice bearing B16melanoma tumor. The M2 is the optimal MR platform for molecular imaging.

Conventional 7 Tesla MRI

M2™ MRI

M2™ MRI

Significant improvements in signal strength and tumor detection are shown for the M2™ platform (right) contrasted to a 7 tesla system (left). Image courtesy of Dr. S. Aime, University of Turino, Italy


Normal mouse anatomy imaged in vivo with contrast agent via IV injection

M2™ MRI

Normal mouse anatomy imaged in vivo with contrast agent via IV injection


PhenoQuant™ Molecular Imaging Accessories

Aspect Imaging also sells a variety of PhenoQuant™ accessories to assist in contrast-enhanced molecular imaging Bruker ICON™ and Mediso nanoScan® platforms:

PhenoQuant™ Contrast Imaging Accessories
NEW
PhenoQuant Custom Intravenous Catheter (1 Unit)
PQ-AC-CATH-1
  • Custom MR-compatible butterfly catheter manufactured with 36" PU tubing to accept 27 gauge needle for safe and consistent IV injection or delivery of contrast agents to mice and rats during a Bruker™ ICON imaging session
  • Sterilized
NEW
PhenoQuant Custom Intravenous Catheter (10 Units)
PQ-AC-CATH-10
  • Custom MR-compatible butterfly catheter manufactured with 36" PU tubing to accept 27 gauge needle for safe and consistent IV injection or delivery of contrast agents to mice and rats during a Bruker™ ICON imaging session
  • Sterilized and packaged individually