MRI of tumors in mice at 1 and 7 Tesla with Gadolinium: When the low field is better!

Abstract

Compact MRI at 1 Tesla have many advantages over high-field superconducting MRI but a key imaging benefit is the increased sensitivity for gadolinium-based contrast imaging. This talks explores the many techniques of MR-based contrast imaging including DCE (dynamic contrast-enhanced imaging) which detects and measures enhancement patterns to reflect tumor perfusion and permeability, angiography, vascular changes induced by anti-angiogenic vaccination, Fibrin accumulation in the extravascular compartment of tumor and MRI detection of tumor cells by targeting LDL (Low Density Lipoproteins) receptors with Gd-loaded LDL particles. All contrast imaging is performed on the M2™ compact, high-performance desktop MRI system (Aspect Imaging) and enables the benefit of increased sensitivity of Gd-based contrast agents.

NOTE: This presentation described the Aspect Imaging M2™ compact high-performance MRI system. The system is now available as the Bruker ICON, the standard in pre-clinical compact MRI platforms. The ICON uses Aspect Imaging’s compact magnet, gradients and animal handling systems.

 

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Silvio Aime, Ph.D.

Silvio Aime, Ph.D.

Head, NMR Laboratory of the Department of Chemistry, University of Turino, Italy, Head, Centre of Excellence for Molecular Imaging Turino, Italy

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