Preclinical Imaging

3D MR-Based Histology System

Aspect Imaging’s 3D MR-based histology system allows automated multi-sample ex vivo imaging of fixed samples and embryos for toxicological and developmental studies. The histology system works with any of our M-Series™ Compact MRI systems and transforms high-throughput 3D imaging of fixed samples into a quick, efficient and simple task for the modern toxicology lab or researcher. The system is designed for high spatial resolution, enabling easy-to-use multisample ID and data management.

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System Features

STEP 1

Samples are placed in cartridges.

Fixed samples (whole organs or tissue samples) are placed in the cartridges. As MR imaging is non-destructive, the tissue remains unchanged, and routine immunohistochemistry is easily performed following the 3D MR-based histology.

STEP 2

Custom bar codes are printed and samples are scanned.

The system produces unique bar code stickers which are applied to each cartridge. The cartridge is scanned and the study software brought up, which allows the operator to enter study-specific and sample specific data. The appropriate imaging protocol is selected and associated with the sample bar code.

STEP 3

Up to 9 cartridges are pre-loaded.

The “auto-loader” allows up to 9 cartridges to be pre-loaded. A sample is advanced into the system, its bar code is read and the appropriate protocol run. The next sample is automatically advanced, starting the process again.

STEP 4

Easy-to-manage high-throughput 3D MR-based histology.

The system can automatically generate high-resolution 3D data sets of up to 10 samples. A quick sample can be run in a few minutes, or can be set-up and the samples run overnight, unattended.