Compact MRI at 1 Tesla have many advantages over high-field superconducting MRI but a key imaging benefit is the increased sensitivity for gadolinium-based contrast imaging. This talks explores the many techniques of MR-based contrast imaging including DCE (dynamic contrast-enhanced imaging) which detects and measures enhancement patterns to reflect tumor perfusion and permeability, angiography, vascular changes induced by anti-angiogenic vaccination, Fibrin accumulation in the extravascular compartment of tumor and MRI detection of tumor cells by targeting LDL (Low Density Lipoproteins) receptors with Gd-loaded LDL particles. All contrast imaging is performed on the M2™ compact, high-performance desktop MRI system (Aspect Imaging) and enables the benefit of increased sensitivity of Gd-based contrast agents.
NOTE: This presentation described the Aspect Imaging M2™ compact high-performance MRI system. The system is now available as the Bruker ICON, the standard in pre-clinical compact MRI platforms. The ICON uses Aspect Imaging’s compact magnet, gradients and animal handling systems.
Silvio Aime, Ph.D.
Head, NMR Laboratory of the Department of Chemistry, University of Turino, Italy, Head, Centre of Excellence for Molecular Imaging Turino, Italy